A hierarchical functional data analytic approach for analyzing physiologically based pharmacokinetic models
نویسندگان
چکیده
منابع مشابه
a new approach to credibility premium for zero-inflated poisson models for panel data
هدف اصلی از این تحقیق به دست آوردن و مقایسه حق بیمه باورمندی در مدل های شمارشی گزارش نشده برای داده های طولی می باشد. در این تحقیق حق بیمه های پبش گویی بر اساس توابع ضرر مربع خطا و نمایی محاسبه شده و با هم مقایسه می شود. تمایل به گرفتن پاداش و جایزه یکی از دلایل مهم برای گزارش ندادن تصادفات می باشد و افراد برای استفاده از تخفیف اغلب از گزارش تصادفات با هزینه پائین خودداری می کنند، در این تحقیق ...
15 صفحه اولProposed Approach to Efficiently Develop Physiologically Based Pharmacokinetic (PBPK) & Physiologically Based Pharmacokinetic-Pharmacodynamic (PBPK-PD) Models for Pesticides
The standard approach to extrapolating from animals to humans (inter-species) or across the human population (intra-species) in risk assessment is to apply 10X uncertainty factors. In Science and Decisions: Advancing Risk Assessment (NRC, 2009), the NAS recommends that the agency “...continue and expand use of the best, most current science to support and revise default assumptions.” EPA publis...
متن کاملHIERARCHICAL DATA CLUSTERING MODEL FOR ANALYZING PASSENGERS’ TRIP IN HIGHWAYS
One of the most important issues in urban planning is developing sustainable public transportation. The basic condition for this purpose is analyzing current condition especially based on data. Data mining is a set of new techniques that are beyond statistical data analyzing. Clustering techniques is a subset of it that one of it’s techniques used for analyzing passengers’ trip. The result of...
متن کاملPhysiologically based pharmacokinetic models for trichloroethylene and its oxidative metabolites.
Trichloroethylene (TCE) pharmacokinetics have been studied in experimental animals and humans for over 30 years. Compartmental and physiologically based pharmacokinetic (PBPK) models have been developed for the uptake, distribution, and metabolism of TCE and the production, distribution, metabolism, and elimination of P450-mediated metabolites of TCE. TCE is readily taken up into systemic circu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmetrics
سال: 2013
ISSN: 1180-4009
DOI: 10.1002/env.2198